http://www.creativepro.com/story/howto/24850.html?cprose=8-20
This article reviews how viewing certain fonts is much different when displayed at a small size vs. a larger one. Most Sans serif look good and are legible at small and large font sizes. Whereas, serif fonts tend to only be legible at larger font sizes. Heavey fonts look good at large sizes, also. The article suggests ajusting tracking and kerning. Tracking is the adjustment of space for groups of letters and entire blocks of text. Kerning is the adjustment of space between pairs of letters. It suggests adjust the size of the font, then the tracking, then the kerning, in that order.